The American Society for Reproductive Medicine published the results of a trial to determine if Pre-Implementation Genetic Diagnosis (PGD) can increase the rates of successful pregnancies. PGD is the process by which chromosomal abnormalities in the embryo are detected prior to implantation.The study looked at implantation and delivery rates for infertile couples in whom the female partner (or egg donor) is between the sages of 21 and 42 years who are attempting conception through IVF.
The study was published by the U.S. National Library of Medicine and the National Institutes of Health.
The results showed that indeed, the blastocysts that underwent comprehensive chromosomal screening results in statistically significantly improved IVF outcomes. This was evidenced by a meaningful increase in sustained implantation and higher delivery rates.
In the trial, 134 blastocysts were transferred to 72 patients in the comprehensive chromosome screening (CCS) group and 163 blastocysts to 83 patients in the routine care (control) group. Sustained implantation rates (probability that an embryo will implant and progress to delivery) were statistically significantly higher in the CCS group (89 of 134; 66.4%) compared with those from the control group (78 of 163; 47.9%). Delivery rates per cycle were also statistically significantly higher in the CCS group. Sixty one of 72 treatment cycles using CCS led to delivery (84.7%), and 56 of 83 (67.5%) control cycles ultimately delivered. Outcomes were excellent in both groups, but use of CCS clearly improved patient outcomes.
At CACRM, we offer Pre-Implementation Genetic Diagnosis (PGD) and Pre-Implementation Genetic Screening (PGS). As a fertility specialist for over 20 years with a special interest in Pre-implantation Genetic Diagnosis (PGD) and Recurrent Pregnancy Loss, Dr. Lori Arnold has always strongly encouraged the use of PGD for her patients. The screening not only increases pregnancy success rates, but can identify inherited genetic disorders that can compromise your building a healthy family. Learn more.